Sparstolonin B

Research use only, not for human use.

Sparstolonin B, a selective TLR2 and TLR4 antagonist, is an isocoumarin compound isolated from the tubers of Sparganium stoloniferum and Scirpus yagara with anti-HIV, anticancer, antitumour and anti-inflammatory activities.

Sparstolonin B acts as a selective TLR2 and TLR4 antagonist and selectively blocks TLR2- and TLR4-mediated inflammatory signaling. Sparstolonin B has anti-HIV and anticancer activities.

Sparstolonin B (1-20 μM; 2-4 days) inhibits cell growth and viability of neuroblastoma cells.Sparstolonin B inhibits TLR ligand-induced cytokine expression in mouse macrophages. Sparstolonin B inhibits MyD88 recruitment to TLR4 and TLR2.Sparstolonin B generates reactive oxygen species (ROS) in neuroblastoma cells. Sparstolonin B reduces expression of N-myc in neuroblastoma cells.Cell Viability Assay Cell Line:SH-SY5Y, IMR-32, NGP, SKNF-1 and SK-N-BE(2) cells Concentration:1 μM, 5 μM, 10 μM or 20 μM Incubation Time:2-4 days Result:Effectively and dose-dependently inhibits the viability of all neuroblastoma cell lines after 2 days (SH-SY5Y and IMR-32), 3 days (NGP cells) or 4 days (SKNF-1 and SK-N-BE(2) cells) treatment.

Sparstolonin B (100 μg/mouse; i.p.) suppresses LPS-provoked inflammation in mice.Animal Model:5-6-week-old male C57Bl/6 mice (body weight 18-20 g) Dosage:100 μg/mouse Administration:I.p.Result:Significantly lower TNFα and IL-1β expression levels in LPS-induced sepsis mouse model.

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Immunology/Inflammation

TLR

TLR | HIV Protease

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1259330-61-4

268.22

C15H8O5

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (37.28 mM)

Oc1ccc2oc3ccc(O)c4c3c(coc4=O)c2c1

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(-20℃)

With Ice Pack

≥ 2 years